Biochemical and pharmacological studies on amineptine
(S 1694) and (+)-amphetamine in the rat

by
Samanin R, Jori A, Bernasconi S, Morpugo E, Garattini S.
J Pharm Pharmacol. 1977 Sep;29(9):555-8.


ABSTRACT

Ahe pharmacological activities of amineptine (S 1694) and (+)-amphetamine and their interaction with biogenic amines have been examined in rats. The locomotor activity, stereotyped behaviour and hypothermia induced by amineptine were similar to but not as marked as those produced by (+)-amphetamine, and there was little or no anorectic action. Amineptine does not modify the concentrations of brain noradrenaline or acetylcholine which are respectively reduced and increased by (+)-amphetamine. Moreover, amineptine does not affect significantly the decrease of brain noradrenaline induced by an intraventricular injection of 6-hydroxydopamine, an effect significantly antagonized by (+)-amphetamine. On the other hand, like amphetamine, amineptine significantly reduces the effect of 6-hydroxy-dopamine on brain dopamine. Both drugs increase the striatal concentrations of homovanillic acid and show a cross tolerance in this action. Therefore they could act similarly on the striatal dopaminergine system. Amineptine thus appears to be a new type of antidepressant with a brain biochemical profile differing from that of other drugs used in depressive disorders.


Efficacy
Early onset?
Comparisons
Pharmacology
Amineptine excess
Amineptine and sex
Mesolimbic dopamine
Amineptine and the rat
Dopaminergic fast actors
Amineptine and smart mice
Amineptine and smarter dogs
Amineptine for amphetamine withdrawal
Amineptine, cocaine and the undiscriminating mouse



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