Cross-tolerance between amineptine,
an atypical antidepressant and cocaine in mice

by
Filibeck U, Castellano C, Oliverio A
Institute of Psychobiology and Psychopharmacology,
CNR, Rome, Italy.
Funct Neurol 1988 Apr-Jun;3(2):129-36


ABSTRACT

The effects of amineptine and cocaine on locomotor activity were studied in two sets of experiments, by using C57BL/6 mice. In a first set, activity enhancements were evident following acuteadministration of both drugs. In addition to that the effects of amineptine were additive with those of cocaine. In a second set of experiments, mice developed tolerance to the stimulatory effects of both amineptine and cocaine, and a clear cross-tolerance effect was evident in mice chronically injected with these drugs. The results are discussed in terms of the involvement of dopaminergic mechanisms in the activity stimulating action of amineptine.


Efficacy
Metabolism
Pharmacology
Amineptne: Italy
Amineptine excess
Amineptine and sex
Mesolimbic dopamine
Amineptine in Portugal
Amineptine v maprotiline
Amineptine v trimipramine
Amineptine v clomipramine
Amineptine and the elderly
Amineptine and smarter dogs



Refs
and further reading

HOME
HedWeb
Nootropics
Cocaine.org
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family