Dopamine agonist amineptine prevents the
antidepressant effect of sleep deprivation

by
Benedetti F, Barbini B, Campori E, Colombo C, Smeraldi E.
Istituto Scientifico Ospedale San Raffaele,
IRCCS Department of Neuropsychiatric Sciences,
University of Milan School of Medicine, Italy.
Psychiatry Res 1996 Dec 20;65(3):179-84


ABSTRACT

In a double-blind study, the effects of the interaction between the administration of amineptine versus placebo and repeated cycles of total sleep deprivation (TSD), which is thought to act through an enhancement in dopaminergic transmission, were analyzed. Twenty-two consecutively admitted patients with bipolar depression formed the study group. Repeated administrations of TSD significantly enhanced perceived mood levels in placebo-treated patients, while amineptine administration blocked the antidepressant action of TSD. Hypothesized changes in brain dopaminergic transmission attributable to amineptine pretreatment are discussed.


Efficacy
Early onset?
Comparisons
Pharmacology
Amineptine excess
Amineptine and sex
Mesolimbic dopamine
Amineptine and the rat
Dopaminergic fast actors
Amineptine and smart mice
Amineptine and smarter dogs
Amineptine for amphetamine withdrawal
Amineptine, sleep-deprivation and bipolars



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